- An
enamine is an
unsaturated compound derived by the
condensation of an
aldehyde or
ketone with a
secondary amine.
Enamines are
versatile intermediates...
- The
Stork enamine alkylation involves the
addition of an
enamine to a
Michael acceptor (e.g., an α,β -unsaturated
carbonyl compound) or
another electrophilic...
- from o-nitrotoluenes 1.[1][2][3] The
first step is the
formation of an
enamine 2
using N,N-dimethylformamide
dimethyl acetal and pyrrolidine.[4] The desired...
- the β
carbon of the β-ketoesters (2), and
eventually forming an
enamine (3). The
enamine then
attacks the
carbonyl carbon of the α-haloketone (4). This...
- can be
described as
performing either enamine catalysis (by
forming catalytic quantities of an
active enamine nucleophile) or
iminium catalysis (by forming...
- the
modern field of
asymmetric organocatalysis.
Researches on
asymmetric enamine catalysis applied to
important intermediates in
steroids synthesis is due...
- reactions. In 1963, G.
Stork reported the
first enamine alkylation reaction for
ketones -
Stork enamine alkylation reaction. In 1976,
Meyers reported the...
- of
proline in the
transition state determine the
reaction outcome. An
enamine is
formed during the
reaction and only one
proline molecule is involved...
-
aldehydes toward nucleophilic addition by
formation of
enamines (e.g. used in the
Stork enamine alkylation):
International Union of Pure and
Applied Chemistry...
- pattern. Non-carbon
nucleophiles such as water, alcohols, amines, and
enamines can also
react with an α,β-unsaturated
carbonyl in a 1,4-addition. Some...
