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Sulfanilamide (also
spelled sulphanilamide) is a
sulfonamide antibacterial drug. Chemically, it is an
organic compound consisting of an
aniline derivatized...
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Elixir sulfanilamide was an
improperly prepared sulfonamide antibiotic that
caused m****
poisoning in the
United States in 1937. It is
believed to have...
- the
inactive dye
portion a smaller, colorless,
active compound called sulfanilamide. The
discovery helped establish the
concept of "bioactivation" and dashed...
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became the
first oral
version of
sulfanilamide by Bayer,
which had
actually obtained a
German patent on
sulfanilamide as
early as 1909,
without realizing...
- the
elixir sulfanilamide disaster of 1937,
described as one of the most
consequential m****
poisonings of the 20th century.
Elixir sulfanilamide was formulated...
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Neosalvarsan 1935 –
Prontosil (an oral
precursor to
sulfanilamide), the
first sulfonamide 1936 –
Sulfanilamide 1938 –
Sulfapyridine (M&B 693) 1939 – sulfacetamide...
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aniline derivative and a
coupling agent. The most
common arrangements use
sulfanilamide and N-(1-naphthyl)ethylenediamine: a
typical commercial Griess reagent...
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influenced by the
death of more than 100
patients due to
elixir sulfanilamide, a
sulfanilamide medication where the
toxic solvent diethylene glycol was used...
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regulation of drug
development and drug sales. In the U.S., the
Elixir Sulfanilamide disaster led to the
establishment of the Food and Drug Administration...
- chlorothiazide, the
first thiazide diuretic and
developed from the
antibiotic sulfanilamide,
which became available in 1958. Subsequently, beta blockers, calcium...