-
Presenilins are a
family of
related multi-p****
transmembrane proteins which constitute the
catalytic subunits of the gamma-secretase
intramembrane protease...
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Presenilin-1 (PS-1) is a
presenilin protein that in
humans is
encoded by the PSEN1 gene.
Presenilin-1 is one of the four core
proteins in the
gamma secretase...
-
mutation in one of at
least three genes,
which code for
presenilin 1,
presenilin 2, and APP. The
presenilin 1 gene (PSEN1
located on
chromosome 14) was identified...
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Presenilin-2 is a
protein that (in humans) is
encoded by the PSEN2 gene. Alzheimer's
disease (AD)
patients with an
inherited form of the
disease carry...
- four
individual proteins: PSEN1 (
presenilin-1), nicastrin, APH-1 (anterior pharynx-defective 1), and PEN-2 (
presenilin enhancer 2).
Recent evidence suggests...
- PSENEN,
formally PEN-2 (
presenilin enhancer 2), is a
protein that is a
regulatory component of the
gamma secretase complex, a
protease complex responsible...
- amyloid-beta
precursor protein (APP) and
presenilins PSEN1 and PSEN2. Most
mutations in the APP and
presenilin genes increase the
production of a small...
- (S2P) and S2P-like
proteases Aspartyl proteases: this
group includes presenilin, the
active subunit of
gamma secretase and
signal peptide peptidases (SPPs)...
- β-catenin and γ-catenin, δ-catenins seem to
interact with
presenilins.
These catenin-
presenilin interaction have
implications for
cadherin function and...
- PSEN1 (
presenilin-1),
which is the
catalytically active component of the complex, APH-1 (anterior pharynx-defective 1), and PEN-2 (
presenilin enhancer...
