-
Picrotoxin, also
known as cocculin, is a
poisonous crystalline plant compound. It was
first isolated by the
French pharmacist and
chemist Pierre François...
-
convulsant potency was
strongly correlated to in
vitro affinity to the
picrotoxin binding site on the
GABAA receptor complex. Many
GABAA receptor ligands...
- काकमारी) is a
Southeast Asian and
Indian climbing plant. It is the
source of
picrotoxin, a
poisonous compound with
stimulant properties. The
plant is large-stemmed...
-
Clomethiazole acts as a
positive allosteric modulator at the barbiturate/
picrotoxin site of the
GABAA receptor. It
works to
enhance the
action of the neurotransmitter...
- by
interacting with the
GABAA receptor-chloride
channel complex at the
picrotoxin binding site. In humans,
lindane affects the
nervous system, liver, and...
-
alcohol (ethanol),
inhaled anaesthetics, kavalactones, cicutoxin, and
picrotoxin,
among others.
Binding of GABA to the
GABAAR causes the
receptor to shift...
- Both
inhibition by
nerve stimulation and by
applied GABA are
blocked by
picrotoxin. GABA is
primarily synthesized from
glutamate via the
enzyme glutamate...
- been
recognized that, for
neurons that are
stimulated by
bicuculline and
picrotoxin, the fast
inhibitory response to GABA is due to
direct activation of an...
-
drugs such as
barbiturates (Phenobarbital, pentobarbital), steroids, and
picrotoxin.
Benzodiazepines (Valium) bind to the α and γ
subunits of GABA receptors...
- the
GABAA receptor. Its
binding site
seems to be
similar to the one of
picrotoxin, a
potent neurotoxin and convulsant. The
binding of U-93631 decreases...
