-
specific checkpoint in the cell cycle. The
binding of SeqA
protein to
hemimethylated GATC
sequences is
important in the
negative modulation of chromosomal...
-
methylates GATC DNA sequences, DNA
synthesis results in
hemimethylated sequences. This
hemimethylated DNA is
recognized by the
protein SeqA,
which binds and...
-
region is
either methylated or
hemimethylated. This
could occurs through binding of YccV
itself to
fully or
hemimethylated DNA. In addition,
studies have...
- base on the
daughter strand and
binds the
mutated DNA. MutH
binds at
hemimethylated sites along the
daughter DNA, but its
action is latent,
being activated...
-
preference for
hemimethylated DNA and
interacts with the
proliferating cell
nuclear antigen (PCNA). By
preferentially modifying hemimethylated DNA, DNMT1...
- of GATC
sites in the E. coli
genome changes from
fully methylated to
hemimethylated. This is
because adenine introduced into the new DNA
strand is unmethylated...
- with this role, it has a
strong preference towards methylating CpGs on
hemimethylated DNA. However, DNMT1 can
catalyze de novo DNA
methylation in specific...
- methylase, and therefore,
immediately after replication, the DNA will be
hemimethylated. A
repair enzyme, MutS,
binds to
mismatches in DNA and
recruits MutL...
-
enhances the
endonucleasic activity of the latter. MutH
recognizes hemimethylated 5'—GATC—3'
sites and
cleaves next to the G of the non-methylated strand...
-
target site is unmodified, the DNA is cut. When the
target site is
hemimethylated, the
complex acts as a
maintenance methyltransferase,
modifying the...
