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Granulysin (GNLY) is a
protein expressed in most
mammals which functions as an
antimicrobial peptide released by
killer lymphocytes in
cytotoxic granules...
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release of a
number of molecules,
including perforin,
granzyme B, and
granulysin.
Other agents,
including tumor necrosis factor alpha and Fas ligand, also...
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somatic cells, TC
cells release the
cytotoxins perforin, granzymes, and
granulysin.
Through the
action of perforin,
granzymes enter the
cytoplasm of the...
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allowing ions,
water and
toxins to enter. The
entry of
another toxin called granulysin (a protease)
induces the
target cell to
undergo apoptosis. T cell killing...
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Krensky AM, Mody CH (September 2004). "NK
cells use
perforin rather than
granulysin for
anticryptococcal activity".
Journal of Immunology. 173 (5): 3357–3365...
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Granule Defensins TLR4
Cathelicidin (LL37) P2X7, FPR2 Eosinophil-derived
neurotoxin TLR2
Granulysin TLR4
Plasma membrane Syndecans TLR4
Glypicans TLR4...
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infected or
dysfunctional somatic cells,
effector CTL
release perforin and
granulysin:
cytotoxins that form
pores in the
target cell's
plasma membrane, allowing...
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involved in
immune system defense against microbial disease (example:
granulysin is
protective against Mycobacterium tuberculosis ) or are
targeted receptors...
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member of the
SAPLIP (saposin-like protein)
family along with amoebapore,
granulysin, acid sphingomyelinase,
surfactant protein B, and the 4
sphingolipid activator...
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cytotoxic factors like the
granzymes GZMA, GZMB, GZMH,
perforin PRF1, and
granulysin GNLY.
Chemokine ligands CXCL9, CXCL10, and CCL5 that bind to chemokine...
