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Lithium diisopropylamide (commonly
abbreviated LDA) is a
chemical compound with the
molecular formula LiN(CH(CH3)2)2. It is used as a
strong base and has...
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liquid with an ammonia-like odor. Its
lithium derivative,
lithium diisopropylamide,
known as LDA is a
widely used reagent.
Diisopropylamine is a common...
- non-nucleophilic base with an
approximate pKa of 26 (compare to
lithium diisopropylamide, at 36).[citation needed] In the
solid state, the
unsolvated compound...
- species, the pKas of the
conjugate acids are
around 35–40.
Lithium diisopropylamide (LDA), pKa = 36 Silicon-based amides, such as
sodium and pot****ium...
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mixed Claisen condensations, a non-nucleophilic base such as
lithium diisopropylamide, or LDA, may be used,
since only one
compound is enolizable. LDA is...
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lithium amides, e.g.
lithium bis(trimethylsilyl)amide and
lithium diisopropylamide, are also
subject to aggregation.
Lithium amides adopt polymeric-ladder...
- can
undergo deprotonation at low
temperature (−78 °C) with
lithium diisopropylamide as the base to form a
carbamoyl anion stable at
these temperatures...
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Collidinium p-toluenesulfonate
Pyridinium chloride Tetrasodium EDTA
Lithium diisopropylamide Lithium bis(trimethylsilyl)amide Pot****ium
trispyrazolylborate List...
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group can be
converted to
dianions with
strong bases like
lithium diisopropylamide.
These react with
alkyl halides to give derivatives:: 474 RCH2COO−...
- quantitative.
Typically enolates are
generated from
using lithium diisopropylamide (LDA). Often, as in
conventional Claisen condensations,
Mannich reactions...
