- fluoride, is a hydrofluoroolefin. This colorless,
flammable gas is a
difluorinated derivative of ethylene.
Global production in 1999 was approximately...
- with
lithium enolates.
Other metal enolates afforded large amounts of
difluorinated products.
Although the use of
molecular fluorine as an electrophilic...
-
titanium catalyzed reaction of
chlorodifluoromethyl ketones leading to α,α-
difluorinated β-hydroxy ketones".
Chemistry Letters. 13 (7): 1165–1168. doi:10.1246/cl...
- Baskin, J. M.; Agard, N. J.; Bertozzi, C. R. (2008). "Second-Generation
Difluorinated Cyclooctynes for Copper-Free
Click Chemistry". J. Am. Chem. Soc. 130...
-
Staudinger ligation.
After OCT and **** (monofluorinated cyclooctyne), the
difluorinated cyclooctyne (DIFO) was developed. An
improved synthetic approach to...
- solubility, but it
still had poor kinetics.
Monofluorinated (****) and
difluorinated (DIFO)
cyclooctynes were
created to
increase the rate
through the addition...
- ω-hydroxy
ester building blocks for pharmaceuticals, β-hydroxy-α,α-
difluorinated phosphonates and
novel side
chain analogs for the Taxotère
family of...
- "Invention of MK-7845, a SARS-CoV-2 3CL
Protease Inhibitor Employing a
Novel Difluorinated Glutamine Mimic".
Journal of
Medicinal Chemistry. 67 (5): 3935–3958...
-
ketimines by
chiral phosphoric acid-catalyzed Mukaiyama–Mannich reaction.
Difluorinated silyl enol
ethers are
involved to
produce enantioenriched fluoroalkyl-functionalized...
-
difluoromethyl moiety from
difluorocarbene and
transformations of α,α-
difluorinated phosphonium salts. The
development of
methods for the
introduction of...
