-
Afucosylated monoclonal antibodies are
monoclonal antibodies engineered so that the
oligosaccharides in the Fc
region of the
antibody do not have any fucose...
- and
thereby reduce antigen-dependent
cellular cytotoxicity. Therefore,
afucosylated monoclonal antibodies have been
designed to
recruit the
immune system...
- million.
Pharmaceuticals business The
company developed a
method to make
afucosylated monoclonal antibodies using a CHO cell line in
which ****8 has been knocked...
-
historically been
shown to
impact ADCC in adhesion-deficient cells.
Afucosylated monoclonal antibodies Hashimoto, G.; Wright, P. F.; Karzon, D. T. (1983-11-01)...
- 2023). "Understanding antibody-dependent
enhancement in dengue: Are
afucosylated IgG1s a concern?". PLOS Pathogens. 19 (3): e1011223. doi:10.1371/journal...
- Mogamulizumab, sold
under the
brand name Poteligeo, is a humanized,
afucosylated monoclonal antibody targeting CC
chemokine receptor 4 (CCR4). The U.S...
-
Swiss company GlycArt Biotechnology in
order to
acquire technology to
afucosylate antibodies; one of its
products in
development was obinutuzumab, which...
- A. L.; Richardson, P; Munshi, N. C.; Anderson, K. C. (2014). "Novel
afucosylated anti-B cell
maturation antigen-monomethyl
auristatin F antibody-drug...
-
company of the
Swiss Federal Institute of
Technology in
Zurich to
develop afucosylated monoclonal antibodies; GA101 was one of its lead
products when it was...
- the
infamous human anti-mouse
antibody (HAMA).
Further advantages show
afucosylated recombinant antibodies which are used
successfully in the
fight against...
