-
conserved glycoprotein is a
precursor for 4
cleavage products:
saposins A, B, C, and D.
Saposin is an
acronym for
Sphingolipid Activator PrO[S]teINs. Each...
- The
saposin domains refers to two evolutionally-conserved
protein domains found in
saposin and
related proteins (SAPLIP).
Saposins are
small lysosomal...
- that
codes for
saposin is
called prosaposin. It is a
precursor for four
cleavage products, the
saposins A, B, C, and D. The four
saposin domains most likely...
-
requires the
activating protein Saposin C as well as
negatively charged lipids for
maximal catalytic activity. The role of
Saposin C is not known; however, it...
- sphingomyelinase,
surfactant protein B, and the 4
sphingolipid activator proteins (
saposins). The
larger subunit, of 50 kDa,
contains the
active site
serine and the...
- of the lung.
Humans and
animals born with a
congenital absence of the
saposin family SP-B
experience intractable respiratory failure whereas those born...
- (2016-07-31). "Structure of
Human Acid
Sphingomyelinase Reveals the Role of the
Saposin Domain in
Activating Substrate Hydrolysis".
Journal of
Molecular Biology...
- Deficiency". GeneReviews, 2006
Kishimoto Y,
Hiraiwa M, O'Brien JS (Sep 1992). "
Saposins: structure, function, distribution, and
molecular genetics". J.
Lipid Res...
- galactosylceramidase. In rare cases, it may be
caused by a lack of
active saposin A (a
derivative of prosaposin). The
buildup of
unmetabolized lipids adversely...
- surfactant-****ociated
protein B (pulmonary
surfactant regulation) and the
saposins (sphingolipid degradation) of
which SAPLIPs are
named after.
Specific to...
