-
conserved glycoprotein is a
precursor for 4
cleavage products:
saposins A, B, C, and D.
Saposin is an
acronym for
Sphingolipid Activator PrO[S]teINs. Each...
-
sections of the
protein are removed; this
relationship is
found between saposin and swaposin.
Fission and
fusion occurs when
partial proteins fuse to form...
- The
saposin domains refers to two evolutionally-conserved
protein domains found in
saposin and
related proteins (SAPLIP).
Saposins are
small lysosomal...
-
requires the
activating protein Saposin C as well as
negatively charged lipids for
maximal catalytic activity. The role of
Saposin C is not known; however, it...
-
independent entity separate from its
parent AP, is
homologous to
saposin and
belongs to the
saposin-like
protein family (SAPLIP).
Although the PSI is grouped...
-
Combined Saposin Defiency is a very rare
metabolic and
genetic disorder that is
caused by the
mutation in a gene PSAP. This
disease belongs to Lysosomal...
- galactosylceramidase. In rare cases, it may be
caused by a lack of
active saposin A (a
derivative of prosaposin). The
buildup of
unmetabolized lipids adversely...
- is not
activated – the
resulting disease is
saposin B deficiency,
which presents similar to MLD.
Saposin B
Deficiency is very rare, much more rare than...
- Niemann–Pick
disease Type A Type B
Sulfatidosis Metachromatic leukodystrophy Saposin B
deficiency Multiple sulfatase deficiency Mucopolysaccharidoses Type I...
- of
about 14 kDa (including glycosylation), is a
member of the
SAPLIP (
saposin-like protein)
family along with amoebapore, granulysin, acid sphingomyelinase...
