-
Activities of MDMA
Target Affinity (Ki, nM)
SERTTooltip Serotonin transporter 0.73–13,300 (Ki) 380–2,500 (IC50Tooltip half-maximal
inhibitory concentration)...
- α1A-adrenergic receptor, the
dopamine D2 receptor, or the
monoamine transporters (
SERTTooltip serotonin transporter,
NETTooltip norepinephrine transporter, or DATTooltip...
-
antagonist of the NMDA
receptor via the MK-801/PCPTooltip
phencyclidine site
SERTTooltip Serotonin transporter and
NETTooltip norepinephrine transporter blocker...
- PCP site 1) and the common/main
sites on the
monoamine transporters (
SERTTooltip serotonin transporter,
DATTooltip dopamine transporter,
NETTooltip norepinephrine...
-
Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
-
Cyclobenzaprine (and metabolite) Site CBP NCBP
Action SERTTooltip Serotonin transporter 108 ND
Inhibitor NETTooltip Norepinephrine transporter 36 ND Inhibitor...
- (mouse) 1,400 (EC50) (rat) 9,700 (EC50) (mouse) >20,000 (EC50) (human)
SERTTooltip Serotonin transporter >30,000 (Ki) >100,000 (IC50Tooltip half-maximal...
- 500 (EC50) (rodent) >10,000 (EC50) (human) σ1 5,209 σ2 >10,000 I1 650
SERTTooltip Serotonin transporter 3,742–6,000 (Ki) 2,962–3,100 (IC50Tooltip Half-maximal...
-
Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
- 17,000 (Ki) (mouse) 920–2,700 (EC50) (rodent) >30,000 (EC50) (human)
SERTTooltip Serotonin transporter 3,800–>10,000 (Ki) 662–3,900 (IC50Tooltip half-maximal...
