-
Proteostasis is the
dynamic regulation of a balanced,
functional proteome. The
proteostasis network includes competing and
integrated biological pathways...
-
being toxic, has been
proposed as a
major contributor to the disease.
Proteostasis disruption and the
dysfunction of cell organelles,
including endosomes...
- temperatures,
oxidative stress, and
heavy metals. In a
normal cell,
proteostasis (protein homeostasis) must be
maintained because proteins are the main...
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Telomere shortening (or
telomere attrition)
Epigenetic alterations Loss of
proteostasis macroautophagy Antagonistic hallmarks (responses to damage) Deregulated...
- of ‘induced proximity’ in drug development, specifically,
controlled proteostasis, i.e., the
pharmacological modulation of
protein turnover. In 2001, Crews...
- hypergravity, and food restriction. The
example of heat
shock refers to the
proteostasis network. The
addition of a bit of
stress on the cell can lead to activation...
- of
Biology at
Stanford University. He is most
known for his work on
proteostasis,
particularly the role of
ubiquitin and
UFMylation in
protein and ribosome...
-
metabolism Mitochondrial diseases Phosphorus metabolism disorders Porphyrias Proteostasis deficiencies Metabolic skin
diseases Wasting syndrome Water-electrolyte...
- and
identified lineage-specific
variants affecting DNA
repair genes,
proteostasis,
metabolism regulation and
immune response as key
processes during the...
-
pleiotropic role in the
regulation of metabolism, inflammation, autophagy,
proteostasis,
mitochondrial physiology, and
immune responses.
Several drugs that stimulate...
