-
Ubiquitin is a
small (8.6 kDa)
regulatory protein found in most
tissues of
eukaryotic organisms, i.e., it is
found ubiquitously. It was
discovered in...
- the
Ubiquitin-activating
enzyme (E1),
Ubiquitin-conjugating
enzyme (E2), and
ubiquitin ligases (E3). Once a
protein is
tagged with a
single ubiquitin molecule...
- A
ubiquitin ligase (also
called an E3
ubiquitin ligase) is a
protein that
recruits an E2
ubiquitin-conjugating
enzyme that has been
loaded with ubiquitin...
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Ubiquitin carboxy-terminal
hydrolase L1 (EC 3.1.2.15,
ubiquitin C-terminal hydrolase, UCH-L1) is a
deubiquitinating enzyme. UCH-L1 is a
member of a gene...
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Ubiquitin-conjugating enzymes, also
known as E2
enzymes and more
rarely as
ubiquitin-carrier enzymes,
perform the
second step in the
ubiquitination reaction...
-
Ubiquitin-activating enzymes, also
known as E1 enzymes,
catalyze the
first step in the
ubiquitination reaction,
which (among
other things) can target...
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encoded by the UBC gene in humans. Polyubiquitin-C is one of the
sources of
ubiquitin,
along with UBB, UBA52, and RPS27A. UBC gene is one of the two stress-regulated...
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Ubiquitin-binding
domains (UBDs) are
protein domains that
recognise and bind non-covalently to
ubiquitin through protein-protein interactions. As of 2019...
-
ubiquitin proteases,
ubiquitin hydrolases, or
ubiquitin isopeptidases, are a
large group of
proteases that
cleave ubiquitin from proteins.
Ubiquitin is...
-
Ubiquitin-like
proteins (UBLs) are a
family of
small proteins involved in post-translational
modification of
other proteins in a cell,
usually with a...
