-
elegans has two
genes that
resemble the
presenilins and
appear to be
functionally similar, sel-12 and hop-1.
Presenilins undergo cleavage in an
alpha helical...
- a membrane-bound
protein complex called γ-secretase to
generate Aβ.
Presenilins 1 and 2 are the
enzymatic centers of this
complex along with nicastrin...
-
inhibitor binds to the fragments, the
cleaved presenilin complex is
considered to be the
active form.
Presenilins are
postulated to
regulate APP processing...
- calcium-binding
protein that
interacts with the
presenilins and
regulates the
levels of a
presenilin fragment". Nat. Med. 4 (10): 1177–81. doi:10.1038/2673...
- amyloid-beta
precursor protein (APP) and
presenilins PSEN1 and PSEN2. Most
mutations in the APP and
presenilin genes increase the
production of a small...
- β-catenin and γ-catenin, δ-catenins seem to
interact with
presenilins.
These catenin-
presenilin interaction have
implications for
cadherin function and...
-
Presenilins-****ociated rhomboid-like protein,
mitochondrial (PSARL), also
known as PINK1/PGAM5-****ociated rhomboid-like
protease (PARL), is an
inner mitochondrial...
-
Younkin LH,
Wagner SL,
Younkin SG,
Borchelt DR (January 2004). "Mutant
presenilins specifically elevate the
levels of the 42
residue beta-amyloid peptide...
- identified,
specifically amyloid precursor protein (APP),
presenilin 1 (PSEN1), and
presenilin 2 (PSEN2). Over 300
mutations have been
detected in these...
-
include the
discovery of the
presenilins (PSEN1 and PSEN2), Nicastrin, TREM2,
Apolipoprotein E and SORL1 genes.
Presenilin mutations are the most common...
