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Polyubiquitin-C is a
protein encoded by the UBC gene in humans.
Polyubiquitin-C is one of the
sources of ubiquitin,
along with UBB, UBA52, and RPS27A...
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proteins L40 and S27a, respectively. The UBB and UBC
genes code for
polyubiquitin precursor proteins.
Ubiquitylation (also
known as
ubiquitination or...
- and are
instead united by
molecular phylogenies of rRNA and
actin or
polyubiquitin. They were the
first major eukaryotic group to be
recognized mainly...
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other ligases to
attach additional ubiquitin molecules. The
result is a
polyubiquitin chain that is
bound by the proteasome,
allowing it to
degrade the tagged...
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conjugate ubiquitin in a head-to-tail
manner to
generate linear (M1-linked)
polyubiquitin chains. The
complex is
currently known to be
composed of
three proteins:...
- one
ubiquitin molecule,
additional rounds of
ubiquitination form a
polyubiquitin chain that is
recognized by the proteasome's 19S
regulatory particle...
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Another source of free
polyubiquitin is the
product of ubiquitin-substrate cleavage. If DUBs
cleave the base of the
polyubiquitin chain that is attached...
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requires a
dimeric ubiquitin-conjugating
enzyme complex and a
unique polyubiquitin chain". Cell. 103 (2): 351–61. doi:10.1016/s0092-8674(00)00126-4. PMID 11057907...
- response, is
released from
degraded proteins by dis****embly of the
polyubiquitin chains. The dis****embly
process is
mediated by ubiquitin-specific proteases...
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compartments within the cell. BRCA1 polypeptides, in particular, Lys-48-linked
polyubiquitin chains are dis****d
throughout the
resting cell nucleus, but at the...
