- An
oncogene is a gene that has the
potential to
cause cancer. In
tumor cells,
these genes are
often mutated, or
expressed at high levels. Most
normal cells...
-
Oncogene addiction is a
process in
which cancers with genetic, epigenetic, or
chromosomal irregularities become dependent on one or
several genes for maintenance...
- into the host cell or to
enhance already existing oncogenic genes (proto-
oncogenes) in the genome. For example, it has been
shown that
vFLIP and vCyclin...
- Myc is a
family of
regulator genes and proto-
oncogenes that code for
transcription factors. The Myc
family consists of
three related human genes: c-myc...
-
Oncogene is a peer-reviewed
scientific journal published under the
Nature Portfolio addressing cancer cell
genetics and the
structure and
function of oncogenes...
-
factor in many
types of cancer. Akt1 was
originally identified as the
oncogene in the
transforming retrovirus, AKT8. Akt2 is an
important signaling molecule...
- Proto-
oncogene c-KIT is the gene
encoding the
receptor tyrosine kinase protein known as tyrosine-protein
kinase KIT, CD117 (cluster of differentiation...
-
three Ras
genes in
humans (HRAS, KRAS, and NRAS) are the most
common oncogenes in
human cancer;
mutations that
permanently activate Ras are
found in...
-
produce a
functional fusion protein. Many
important cancer-promoting
oncogenes are
fusion genes produced in this way.
Examples include: Gag-onc fusion...
- Proto-
oncogene tyrosine-protein
kinase ROS is an
enzyme that in
humans is
encoded by the ROS1 gene. This proto-
oncogene,
highly expressed in a variety...
