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Nucleophosmin (NPM), also
known as
nucleolar phosphoprotein B23 or numatrin, is a
protein that in
humans is
encoded by the NPM1 gene. In humans, the NPM1...
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requires ATP.
Humans express three members of the
nucleoplasmin family:
Nucleophosmin (NPM1)
Nucleoplasmin 2 (NPM2)
Nucleoplasmin 3 (NPM3)
Dingwall C, Laskey...
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which is
important in rRNA processing. The GC
contains the
protein nucleophosmin, (B23 in the
external image),
which is also
involved in
ribosome biogenesis...
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bordered by the
granular component (GC) (that
contains the
protein nucleophosmin).
Transcription of the rDNA
occurs either in the FC or at the FC-DFC...
- be
performed to look for
specific mutations in
genes such as FLT3,
nucleophosmin, and KIT,
which may
influence the
outcome of the disease. Cytochemical...
- the
kinase domain of ALK is
fused to the amino-terminal part of the
nucleophosmin (NPM) protein.
Dimerization of NPM
constitutively activates the ALK...
-
described in APL
fusing RARA to
promyelocytic leukemia zinc
finger (PLZF),
nucleophosmin,
nuclear matrix ****ociated,
signal transducer and
activator of transcription...
-
responsible for
regulation of
centriole duplication:
nucleophosmin (NPM/B23), CP110, and MPS1.
Nucleophosmin is only
found in
unreplicated centrosomes and its...
-
related to the
nuclear chaperone phosphoproteins,
nucleoplasmin and
nucleophosmin. It is
highly homologous to the
murine Npm3 gene.
Based on the structural...
- co-localizes with RPGRIP1 at
centrioles and
basal bodies and
interacts with
nucleophosmin".
Human Molecular Genetics. 14 (9): 1183–1197. doi:10.1093/hmg/ddi129...
