-
reaction of
lipoic acid biosynthesis, is impaired. The
result is a
reduced lipoylation degree of
important mitochondrial enzymes, such as
pyruvate dehydrogenase...
-
precursor reaction of
lipoic acid biosynthesis. The
result is a
reduced lipoylation degree of
important mitochondrial enzymes, such as
oxoglutarate dehydrogenase...
- extensions.
Through lipoic acid as a
cofactor respectively the
degree of
lipoylation,
mtFASII has an
influence on
mitochondrial enzyme complexes in energy...
- (GPI)
anchor formation via an
amide bond to C-terminal tail
lipoylation (a type of acylation),
attachment of a
lipoate (C8)
functional group...
-
partially redundant role in
lipoic acid
synthesis and thus in
protein lipoylation by
providing malonyl-CoA for
mitochondrial fatty acid
synthesis (mtFASII)...
- glutamylation, glycosylation, glycylation, hydroxylation, isoprenylation,
lipoylation, methylation, nitroalkylation, phosphopantetheinylation, phosphorylation...
-
direct precursor in
lipoic acid synthesis, this
results in
diminished lipoylation,
since lipoic acid acts as an
essential cofactor for
several mitochondrial...
-
nitrogen compound metabolic process lipoate biosynthetic process protein lipoylation neural tube
closure inflammatory response response to
oxidative stress...
-
Biological process glycine decarboxylation via
glycine cleavage system glycine catabolic process methylation protein lipoylation Sources:Amigo / QuickGO...
- (Cronan, 2001). In conclusion, the
thumb functions to
inhibit the
aberrant lipoylation of the
target lysine by
lipoyl protein ligase (Reche and Perham, 1999)...
