- post-transcriptionally,
regulating mRNA
splicing and
transport to the cytoplasm. The
lentiviral proteome consists of five
major structural proteins and
three or four...
-
Lentiviral vectors in gene
therapy is a
method by
which genes can be inserted, modified, or
deleted in
organisms using lentiviruses.
Lentiviruses are a...
- than gamma-retroviral vectors. More specifically, one
study found that
lentiviral vectors did not
cause either an
increase in
tumor incidence or an earlier...
-
libraries created by the
Zhang lab.
Available through Addgene,
these lentiviral libraries respectively target human and
mouse exons, and both are available...
- Gene
therapy using lentiviral vectors was
being explored in
early stage trials as of 2009.[needs update] In a
Phase I
clinical trial of
three patients...
-
human stem
cells using zinc
finger nucleases and integrase-defective
lentiviral vector delivery".
Nature Biotechnology. 25 (11): 1298–306. doi:10.1038/nbt1353...
-
Baltimore D (January 2003). "Inhibiting HIV-1
infection in
human T
cells by
lentiviral-mediated
delivery of
small interfering RNA
against CCR5". Proceedings...
- used in
clinical trials for HIV and SARS-CoV-2, or
cancer vaccines.: 5
Lentiviral vectors based on lentivirus, a retrovirus, can
modify a cell's nuclear...
- has been
engineered into a
viral vector for gene therapy. Like
other lentiviral vectors, FIV
vectors integrate into the
chromosome of the host cell, where...
-
humans were
started in 2014. The
clinical trials ****essed the
safety of
lentiviral vector-modified bone
marrow for
adults with
severe sickle cell disease...
