- In immunology, an
idiotype is a
shared characteristic between a
group of
immunoglobulin or T-cell
receptor (TCR)
molecules based upon the
antigen binding...
- receptors.
Idiotopes are
aggregated into
idiotypes specific to
their target antigen. An
example of an anti-
idiotype antibody is Racotumomab. To
produce an...
-
immunoglobulin (
idiotype or Id). Id-secreting
clones are
identified by a
bioinformatics approach which confirms a
match of each vaccine's
unique idiotype sequence...
- each of
which matches a
different lock (antibody).
Different antibody idiotypes, each have
distinctly formed complementarity-determining regions. Allergen...
-
inactivated in the
normal individual and
cannot amplify the
immune response.
Idiotype network theory,
proposed by Jerne,
wherein a
network of
antibodies capable...
- the
active sites of
antibodies are
attracted to both
specific antigens (
idiotypes) and to
other antibodies that bind to the same site. The
antibodies are...
-
multiple idiotopes; and the set of
these individual idiotopes is
termed the
idiotype of the antibody.
Idiotopes contrast with allotopes,
which are non-varying...
-
Retrieved 27
November 2020.
Yewdell J (4
October 2003). "He put the Id in
Idiotype". EMBO
Reports (Book review). 4 (10): 931. doi:10.1038/sj.embor.embor951...
- Goldman, M; Rose, LM; Hochmann, A; Lambert, PH (1982). "Deposition of
idiotype-anti-
idiotype immune complexes in
renal glomeruli after polyclonal B cell activation"...
- are also
called idiotypes.
According to
immune network theory, the
adaptive immune system is
regulated by
interactions between idiotypes. The Fc region...
