-
interaction with E2F. It
exists in two states:
hypophosphorylated pRb and
hyperphosphorylated pRb.
Hypophosphorylated pRb
binds E2F,
which prevents transcription...
-
circadian pacemaker. In Drosophila,
newly synthesized CLOCK (CLK) is
hypophosphorylated in the
cytoplasm before entering the nucleus. Once in the nuclei,...
-
Mukai H,
Oishi K,
Isagawa T, Ono Y (2000). "****ociation of
immature hypophosphorylated protein kinase cepsilon with an
anchoring protein CG-NAP". J. Biol...
- such as pRB and
related proteins p107 and p130, can bind to E2F when
hypophosphorylated. In activators, E2F
binding with pRB has been
shown to mask the transactivation...
- SF2/ASF
interact when SF2/ASF is
hypophosphorylated during transcription elongation. SR
proteins can
become hypophosphorylated during elongation decreasing...
-
Without Cdk 2,
retinoblastoma protein (pRB)
remains in its active,
hypophosphorylated form and
binds to the
transcription factor E2F1, an
important cell...
- p15INK4b or p16INK4A
keeps the Rb-family
proteins hypophosphorylated. This
allows the
hypophosphorylated Rb to
repress transcription of S-phase
genes causing...
-
progressively dephosphorylated by PP1,
returning to its growth-suppressive
hypophosphorylated state. pRb
family proteins are
components of the
DREAM complex composed...
-
inhibitors including Ink4 and Cip/Kip
family proteins. As a result, Rb is
hypophosphorylated and
inhibits E2F,
promoting quiescence in G0-phase of the cell cycle...
- is
displaced from the eIF3
complex upon
binding of mTOR with eIF3.
Hypophosphorylated S6K is
located on the eIF3
scaffold complex.
Active mTORC1 gets recruited...
