Definition of GSDMD. Meaning of GSDMD. Synonyms of GSDMD

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Definition of GSDMD

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Meaning of GSDMD from wikipedia

- Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily...
- cytosolic gasdermin D (GSDMD). GSDMD can be cleaved to produce an N-terminal domain (GSDMD-N) and a C-terminal domain (GSDMD-C). GSDMD-N can oligomerize and...
- non-infected patients is not uncommon. Gasdermin D (GSDMD) is a protein that in humans is encoded by the GSDMD gene and is a known target of the inflammasome...
- 18 (IL-18), as well as the pore-forming molecule gasdermin D (GSDMD). The N-terminal GSDMD fragment resulting from this cleavage induces a pro-inflammatory...
- HGNC:13311 Q96QA5 6683 GSDMB HGNC:23690 Q8TAX9 6684 GSDMC HGNC:7151 Q9BYG8 6685 GSDMD HGNC:25697 P57764 6686 GSDME HGNC:2810 O60443 6687 GSE1 HGNC:28979 Q14687...
- A crucial downstream substrate for pyroptotic caspases is Gasdermin D (GSDMD) Inflammation is a protective attempt by an organism to restore a homeostatic...
- active pro-inflammatory cytokine forms and b) gasdermin D (also termed GSDMD) into its active form that triggers its parent cell's pyroptosis response...
- activation, the protein gasdermin D (GSDMD) forms pores in the plasma membrane. Kagan and Broz independently found that GSDMD pores serve as membrane channels...
- promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis". Cell Death Discovery. 9 (1): 26. doi:10.1038/s41420-023-01326-z...
- Yinghua; Cai, Tao; Wang, Fengchao; Shao, Feng (2015-10-29). "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death". Nature. 526...