-
surface protein on a T cell, can
produce a
costimulatory signal or a
coinhibitory signal to
enhance or
decrease the
activity of a MHC-TCR
signal between...
- diagnosis, or has been
treated with any
agent directed to
stimulatory or
coinhibitory T-cell
receptor (e.g. PD-1, PD-L1, CTLA-4 , et al.) are not
allowed to...
-
homeostatis of CD4+CD25+
Tregulatory cell, also
known as Tregs. CTLA-4 is a
coinhibitory molecule that is
induced on
activated T cells.
Interaction between CTLA-4...
-
degree of success. This is
accomplished through the
blocking of the
coinhibitory molecule CTLA-4. The
blocking antibody does not
directly target tumor...
- Han X,
Higuchi T,
Zheng L, Sun J, Ye JJ, Chen L (April 17, 2014). "
Coinhibitory receptor PD-1H
preferentially suppresses CD4⁺ T cell-mediated immunity"...
- PMC 6449624. PMID 30984188.
Pasero C,
Olive D (March 2013). "Interfering with
coinhibitory molecules: BTLA/HVEM as new
targets to
enhance anti-tumor immunity"....
- 1074/jbc.M001313200. PMID 10764762.
Sinclair NR (1999). "Why so many
coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083...
-
combined immunodeficiency. The
fluctuant balance between co-stimulatory and
coinhibitory signals that a T cell
receives parti****tes in the initiation, effection...
- TNFRSF25 in
humans may lead to similar, but more controllable,
effects as
coinhibitory receptor blockade targeting molecules such as CTLA-4 and PD-1. GRCh38:...
