Definition of Costimulatory. Meaning of Costimulatory. Synonyms of Costimulatory

- post-translational protein modifications or cytoskeletal remodeling. Another costimulatory receptor expressed on T cells is ICOS ( Inducible Costimulator), which...
- and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the...
- (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor . CD80...
- cytokines IFN-γ and TNF-α to increase expression of MHC molecules and costimulatory receptors on the surface of APCs (antigen-presenting cells). This promotes...
- constant Kd, is 770 nM. PD-L1 also has an appreciable affinity for the costimulatory molecule CD80 (B7-1), but not CD86 (B7-2). CD80's affinity for PD-L1...
- a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity...
- memory cells within clonal expansions. In general, CD28 is a primary costimulatory molecule for T cell activation. But effective co-stimulation is essential...
- Drug Mechanism Type abatacept T-cell costimulatory signal inhibitor bDMARD adalimumab TNF inhibitor bDMARD anakinra IL-1 receptor antagonist bDMARD apremilast...
- Inducible costimulator-ligand (ICOS-L) is a member of the B7 family of costimulatory ligands sharing 19–20% sequence identity with CD80 and CD86. Two splice...
- induces the stimulation of antigen presentation and upregulation of costimulatory molecules (such as CD40, CD80 and CD86) on innate immune cells which...