-
especially in
hepatic cells, to
bioactivate the
prodrugs intracellularly to
active drugs. Type II
prodrugs are
bioactivated extracellularly,
either in the...
-
protoxins into
actual toxins. An
enzyme may be
reversibly or
irreversibly bioactivated. A
major mechanism of
irreversible bioactivation is
where a
piece of...
- Activation-dependent
agents are
relatively inert in
their original form, but are
bioactivated in the body into
metabolites or
intermediaries capable of
damaging human...
-
lungs where it
forms oxidized metabolites that can
induce carcinogen-
bioactivating enzymes.
Results are not
clear for
thyroid cancer. A
Cochrane review...
- or by
facilitated excretion from the body. Also, many
substances are
bioactivated by CYP3A4 to form
their active compounds, and many
protoxins are toxicated...
- and does not need to be
deacetylated at the 6-position in
order to be
bioactivated; this
makes 6-MAM
somewhat more
potent than heroin. 6-MAM is
rarely encountered...
- drugs, such as penicillin, will bind
avidly to proteins.
Others must be
bioactivated into a
toxic compound that will in turn bind to proteins. The second...
- by
facilitated excretion from the body. However, many
substances are
bioactivated by P450s to form
their active compounds like the
antiplatelet drug clopidogrel...
-
Ketamine is also
transformed into
hydroxyketamine (5%). As such,
bioactivated HNK
comprises less than 15% of a dose of ketamine. In
contrast to ketamine...
- Activation-dependent
agents are
relatively inert in
their original form, but are
bioactivated in the body into
metabolites or
intermediaries capable of
damaging human...
