-
hydrolase activity,
converting bioactive hepoxilins to
their inactive trioxilin products (see
below section "Hepoxilin-epoxide hydrolase").
Human EH3...
- non-enzymatically to
their corresponding trihydroxy counterparts, the
trioxilins (TrX). HxA3 and HxB3, in particular, are
being rapidly metabolized to...
- A3 and
hepoxilin B3 to
their tri-hydroxyl products,
trioxolin A3 and
trioxilin B3, respectively.
These reactions in
general inactivate the two biologically...
-
Hepoxilin B3
along with
their respective tri-hydroxyl metabolites,
trioxilin A3 and
trioxilin B3.
These metabolites have been
reported to have anti-inflammatory...
-
hepoxilin A3 (8-hydroxy-11S,12Sepoxy-(5Z,8Z,14Z)-eicosatrienoic acid) to
trioxilin A3 (8,11,12-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid) and hepoxilin...
-
decomposes to a
mixture of
hepoxilins and trihydroxy-eicosatetraenoic
acids (
trioxilins) that
possess R or S
hydroxy and R,S or S,R
epoxide residues at various...
-
levels in skin of
hepoxilins A3 and B3, as well as
their metabolites,
trioxilins A3 and B3, are
greatly reduced. Furthermore, rat Aloxe3 has been implicated...
