-
prostate cancer.
Taxanes present difficulties in
formulation as
medicines because they are
poorly soluble in water. As
their name suggests,
taxanes were first...
- and
include important compounds such as retinol,
phytol or taxadiene.
Taxanes are
class of
diterpenoids featuring a
taxadiene core. They are produced...
-
marine sources, a
controversial programme that led to the
discovery of
taxanes (in 1964) and
camptothecins (in 1966). Both
classes of drug were isolated...
- life
expectancy and
overall life quality. The
optimal dose
scheduling of
taxanes remains unconfirmed, but most
studies find
significant mortality benefit...
- uses to pa****axel, and it is
marketed under the
brand name Taxotere.
Taxanes,
including pa****axel, 10-deacetylbaccatin III,
baccatin III, pa****axel...
-
molecules have
generated significant interest after the
introduction of the
taxanes into
clinical oncology and the
general use of the
vinca alkaloids. Examples...
-
chemically taxane-derived diterpenoids,
which do
occur in nature, in the
genera Taxus and
Austrotaxus of yew trees. The
taxoids class and the
taxanes class...
- chains. It is the side
chains that
provide most of the
activity for
regular taxanes.
Abeotaxanes are
compounds containing 3
altered ring structures, where...
- In enzymology, a
taxane 10beta-hydroxylase (EC 1.14.13.76) is an
enzyme that
catalyzes the
chemical reaction taxa-4(20),11-dien-5alpha-yl
acetate + NADPH...
- In enzymology, a
taxane 13alpha-hydroxylase (EC 1.14.13.77) is an
enzyme that
catalyzes the
chemical reaction taxa-4(20),11-dien-5alpha-ol +
NADPH + H+...
