- with
approximately equal affinity while orexin-B
binds mainly to OX2 and is 5 times less
potent at OX1. The
orexins are
strongly conserved peptides, found...
- glucose-sensing neurons,
which produce orexins. However, it is
unknown how
glucose suppresses the
electrical activity of
orexin cells. A
study from the University...
- An
orexin receptor antagonist, or
orexin antagonist, is a drug that
inhibits the
effect of
orexin by
acting as a
receptor antagonist of one (selective...
-
endogenous agonists orexin-A and
orexin-B,
however there are some subtype-selective non-peptide
antagonists available for
research purposes.
Orexins – dual OX1...
- age-related
sleep disturbances. By
blocking the
actions of
orexins and
modulating sleep–wake cycles,
orexin receptor antagonists like
daridorexant reduce wakefulness...
- 2014.00997. PMC 4157463. PMID 25250003.
Orexins promote both
arousal and
feeding (Sweet et al., 1999). ...
Orexin-A also
influences body temperature. In...
-
Terrett JA,
Elshourbagy NA,
Bergsma DJ,
Yanagisawa M (Feb 1998). "
Orexins and
orexin receptors: a
family of
hypothalamic neuropeptides and G protein-coupled...
-
rodents found that
orexins (derived from Gr**** "orexis"
meaning "appetite")
stimulate appetite,
feeding behavior, and
weight gain
while orexin receptor antagonists...
- 24
August 2010. Li J, Hu Z, de
Lecea L (January 2014). "The hypocretins/
orexins:
integrators of
multiple physiological functions".
British Journal of Pharmacology...
-
January 2020.
Jacobson LH,
Hoyer D, de
Lecea L (May 2022). "Hypocretins (
orexins): The
ultimate translational neuropeptides".
Journal of
Internal Medicine...
