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Neocarzinostatin (NCS) is a
macromolecular chromoprotein enediyne antitumor antibiotic secreted by
Streptomyces macromomyceticus. It
consists of two parts...
- 3-(1-naphthoyl)pyrroles
Natural products containing 1-naphthoic acid
moiety Neocarzinostatin (as 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)
Azinomycin B (as...
-
protein H1.
Neocarzinostatin is an
example of an
enediyne that
undergoes triggering via Myers-Saito cyclization. An
analog of
neocarzinostatin, SMANCS, has...
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Fields Genetics of
cancer Thesis Isolation and
characterization of
somatic cell
mutants resistant to auromomycin,
neocarzinostatin and bleomycin (1987)...
- that of
calicheamicin (C much
greater than T
greater than A = G),
neocarzinostatin (T
greater than A
greater than C
greater than G), or
bleomycin (C greater...
- to
another antibiotic known as
neocarzinostatin which is
approved for
clinical use. As with
dynemicin A,
neocarzinostatin also
interacts with DNA. Myers...
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damage and
mutagenesis by
radiomimetic DNA-cleaving agents: Bleomycin,
neocarzinostatin and
other enediynes".
Mutation Research/Fundamental and
Molecular Mechanisms...
- WA (1978). "Sequence
Cleavage of DNA by the Anti-tumor
Antibiotics Neocarzinostatin and Bleomycin".
Proceedings of the
National Academy of Sciences. 75...
- B/cis-Trikentrin A,
Hongoquercin A,
Incarviatone A, Indoxamycin, Kedarcidin/
Neocarzinostatin,
Kinamycin ,
Lithospermic Acid, M1 PAMs, and VS-548. In the formation...
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Kumamoto University and
became a
professor from 1980.
Maeda developed the
neocarzinostatin "SMANCS" with a
copolymer of
styrene and
maleic acid in 1979. Afterward...
