-
Fluoropyrimidines are a
general class organic compounds in
which the substituent(s)
around a
pyrimidine ring
include at
least one
fluorine atom. The term...
-
indicated for
adults with
metastatic colorectal cancer who
received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy...
- in tumors, more
convenient and
efficacious fluoropyrimidine therapy has been desired. The
fluoropyrimidine component of this drug, trifluridine, was first...
- gastro-esophageal
junction (GEJ)
adenocarcinoma after prior treatment with
fluoropyrimidine- or platinum-containing chemotherapy. The
approval was
based on the...
-
through which it acts. It
belongs to the
class of
medications known as
fluoropyrimidines,
which also
includes 5-FU and tegafur.
Capecitabine was
patented in...
-
dehydrogenase (DPD)
enzyme is
responsible for the
detoxifying metabolism of
fluoropyrimidines, a
class of
drugs that
includes 5-fluorouracil, capecitabine, and...
-
increased doses.
Subtypes of the anti-metabolites are the anti-folates,
fluoropyrimidines,
deoxynucleoside analogues and thiopurines. The anti-folates include...
- used in the
treatment of cancer.
Beside 5-FU,
widely prescribed oral
fluoropyrimidine capecitabine (Xeloda)
could put DPD-deficient
patients at risk of experiencing...
- must not be used in the
following groups:
people receiving another fluoropyrimidine (a
group of
anticancer medicines that
includes tegafur/gimeracil/oteracil)...
-
progressed on at
least two
prior regimens,
including trastuzumab, a
fluoropyrimidine- and a platinum-containing chemotherapy. A
total of 188 parti****nts...
