-
Dihydrofolate reductase, or DHFR, is an
enzyme that
reduces dihydrofolic acid to
tetrahydrofolic acid,
using NADPH as an
electron donor,
which can be...
- (conjugate base
dihydrofolate) (DHF) is a
folic acid (vitamin B9)
derivative which is
converted to
tetrahydrofolic acid by
dihydrofolate reductase. Since...
-
Folinic acid is a form of
folic acid that does not
require activation by
dihydrofolate reductase to be
useful to the body.
Folinic acid was
first made in 1945...
- In enzymology, a
dihydrofolate synthase (EC 6.3.2.12) is an
enzyme that
catalyzes the
chemical reaction ATP + 7,8-dihydropteroate + L-glutamate ⇌{\displaystyle...
- A
dihydrofolate reductase inhibitor (DHFR inhibitor) is a
molecule that
inhibits the
function of
dihydrofolate reductase, and is a type of antifolate....
-
substrates and two products. When
enzymes bind
multiple substrates, such as
dihydrofolate reductase (shown right),
enzyme kinetics can also show the sequence...
-
dihydropteroate diphosphate to
dihydrofolic acid, or
dihydrofolate.
Inhibiting the
production of
dihydrofolate intermediate interferes with the
normal bacterial...
- derivative.
Tetrahydrofolic acid is
produced from
dihydrofolic acid by
dihydrofolate reductase. This
reaction is
inhibited by methotrexate. It is converted...
-
methotrexate for DHFR is
about 1000-fold that of
dihydrofolate. DHFR
catalyses the
conversion of
dihydrofolate to the
active tetrahydrofolate. Tetrahydrofolate...
- the 1970s with
ethyl methanesulfonate to
generate a cell line
lacking dihydrofolate reductase (DHFR) activity,
referred to as CHO-DXB11 (also
referred to...
