-
Dihydrofolate reductase, or DHFR, is an
enzyme that
reduces dihydrofolic acid to
tetrahydrofolic acid,
using NADPH as
electron donor,
which can be converted...
- (conjugate base
dihydrofolate) (DHF) is a
folic acid (vitamin B9)
derivative which is
converted to
tetrahydrofolic acid by
dihydrofolate reductase. Since...
-
animals but not humans. It
works by
blocking folate metabolism via
dihydrofolate reductase in some
bacteria which results in
their death. Trimethoprim...
- In enzymology, a
dihydrofolate synthase (EC 6.3.2.12) is an
enzyme that
catalyzes the
chemical reaction ATP + 7,8-dihydropteroate + L-glutamate ⇌ {\displaystyle...
-
Folinic acid is a form of
folic acid that does not
require activation by
dihydrofolate reductase to be
useful to the body.
Folinic acid was
first made in 1945...
-
steps both
catalyzed by the same enzyme,
dihydrofolate reductase.
Folic acid is
first reduced to
dihydrofolate and then to tetrahydrofolate. Each step...
- A
dihydrofolate reductase inhibitor (DHFR inhibitor) is a
molecule that
inhibits the
function of
dihydrofolate reductase, and is a type of antifolate....
- enzymology, a formate—
dihydrofolate ligase (EC 6.3.4.17) is an
enzyme that
catalyzes the
chemical reaction ATP +
formate +
dihydrofolate ⇌ {\displaystyle \rightleftharpoons...
-
mutagenized with
ethyl methanesulfonate to
generate a cell line
lacking dihydrofolate reductase (DHFR) activity,
referred to as CHO-DXB11 (also
referred to...
-
respiration (glycolysis). When
enzymes bind
multiple substrates, such as
dihydrofolate reductase (shown right),
enzyme kinetics can also show the sequence...