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Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a
folic acid (vitamin B9)
derivative which is
converted to
tetrahydrofolic acid by dihydrofolate...
- tetrahydrofolate, is a
folic acid derivative.
Tetrahydrofolic acid is
produced from
dihydrofolic acid by
dihydrofolate reductase. This
reaction is
inhibited by methotrexate...
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synthetase and
inhibit conversion of PABA and
dihydropteroate diphosphate to
dihydrofolic acid, or dihydrofolate.
Inhibiting the
production of
dihydrofolate intermediate...
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other diaminopyrimidines such as trimethoprim,
inhibits the
reduction of
dihydrofolic acid to
tetrahydrofolic acid by
bacterial cells. Hofacre,
Charles L.;...
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Dihydrofolate reductase, or DHFR, is an
enzyme that
reduces dihydrofolic acid to
tetrahydrofolic acid,
using NADPH as an
electron donor,
which can be converted...
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Trimethoprim binds to
dihydrofolate reductase and
inhibits the
reduction of
dihydrofolic acid (DHF) to
tetrahydrofolic acid (THF). THF is an
essential precursor...
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urinary tract, Shigella, Salmonella, and
Pneumocystis jivoreci infections.
Dihydrofolic acid GHS:
GESTIS 492946 Hevener, Kirk E; Yun, Mi-Kyung; Qi, Jianjun;...
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dihydropteroate synthetase activity,
which in turn
leads to
impaired synthesis of
dihydrofolic acid and as a
result its
active metabolite necessary for the synthesis...
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biosynthesis of
dihydrofolic acid in many microorganisms. The
enzyme dihydropteroate synthetase converts pteridine and 4-aminobenzoic acid to
dihydrofolic acid in...
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dihydrofolate reductase, the
enzyme responsible for the
reduction of
dihydrofolic acid to
tetrahydrofolic acid, but
rather to
defective folate metabolism...
