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Biotransformation is the
biochemical modification of one
chemical compound or a
mixture of
chemical compounds.
Biotransformations can be
conducted with...
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desloratadine N-glucuronide by CYP2C8; and finally, a non-enzymatic
deconjugation of 3-hydroxydesloratadine N-glucuronide. Both
desloratadine and 3-hydroxydesloratadine...
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concentration of β-glucuronidase in
breast milk,
which increases bilirubin deconjugation and
reabsorption of bilirubin,
leading to
persistence of physiologic...
- "Selective
hydrolysis of α,β- and β,γ-unsaturated ketals:
method for
deconjugation of β,β-disubstituted α,β-unsaturated ketones". J. Org. Chem. 43 (9):...
- to
glucuronic acid. In the bladder,
glucuronidase re-activates it by
deconjugation,
which leads to the
development of
bladder cancer.
Naphthalene Naphthol...
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nitrogen source.
Other important functions of
Bacteroides spp.
include the
deconjugation of bile
acids and
growth on mucus. Many
members of the Bacteroidota...
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bacteria colonizing the
small intestines in SIBO may also
cause bile acid
deconjugation leading to
malabsorption of lipids. In a
process called intestinal adaptation...
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although the
extent of
their specificity may not yet be understood.
Deconjugation begins with the
recognition of the substrate,
which consists of a steroid...
- and
progestogen metabolism,
neurosteroid synthesis Conjugation (and
deconjugation)
Glucuronosyltransferase (UGT2Bs) –
steroid metabolism Glucuronidase...
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through bacteria binding bile
acids in the
colon after the
initial deconjugation and dehydroxylation. The
sequestered bile
acids are then
excreted in...
