-
Cyclopamine (11-deoxojervine) is a
naturally occurring steroidal alkaloid. It is a
teratogenic component of corn lily (Veratrum californi****),
which when...
- Washington, Oregon, N
California It is a
source of jervine,
muldamine and
cyclopamine,
teratogens which can
cause prolonged gestation ****ociated with birth...
- process. One
highly teratogenic alkaloid toxin that can
cause cyclopia is
cyclopamine or 2-deoxyjervine,
found in the
plant Veratrum californi**** (also known...
-
consume but
cannot detoxify the alkaloids. One
example is the
alkaloid cyclopamine,
produced in the
leaves of corn lily.
During the 1950s, up to 25% of...
- are
known in nature. For instance, ewes who
graze on corn lily
ingest cyclopamine (shown) and veratramine, two of a sub-family of
steroids where the C-...
-
adding to the
media anti-shh antibodies,
Hedgehog interacting protein, or
cyclopamine,
where the
first two
molecules are
proteins and the last a
small molecule...
-
agents are
cyclopamine-competitive.
Itraconazole (Sporanox) has also been
shown to
target SMO
through a
mechanism distinct from
cyclopamine and vismodegib...
- it is a semi-synthetic
derivative of the
alkaloid cyclopamine. The
process begins with
cyclopamine extracted from
harvested Veratrum californi**** which...
-
cannot be
treated with
surgery or radiation. The
substance acts as a
cyclopamine-competitive
antagonist of the
smoothened receptor (SMO)
which is part...
-
Removal of
atoms from rings:
cyclopamine, an
example of a
complex C-nor-D-homosteroid,
where the C-12 atom is
removed from the
normally 6-membered central...
