- An
autophagosome is a
spherical structure with
double layer membranes. It is the key
structure in macroautophagy, the
intracellular degradation system...
- from the rest of the cell
within a double-membrane
vesicle known as an
autophagosome, which, in time,
fuses with an
available lysosome,
bringing its specialty...
- in
autophagy substrate selection and
autophagosome biogenesis. LC3 is the most
widely used
marker of
autophagosomes. LC3 was
originally identified as a...
- (PAMPs or DAMPs), the
removal of
senescent cells is non-inflammatory.
Autophagosomes are
different from
phagosomes in that they are
mainly used to selectively...
- phagop**** and
eventually become the
contents of the
fully ****embled
autophagosome.
Autophagosome biogenesis requires the
initiation and
growth of phagop****s...
-
sequester portions of the cytosol, the so-called
autophagosomes. The
outer membrane of
these autophagosomes subsequently fuses with the lysosome/vacuole to...
-
signal transduction amplifiers. Recently, σ1R has been
implicated in
autophagosome formation and maturation.
Autophagy is a
broad homeostatic, metabolic...
-
becoming LC3-II.
After formation of the
autophagosome, the ATG12-ATG5:ATG16L
complex dissociates from the
autophagosome. In
instances of
spontaneous apoptosis...
-
section of the cytoplasm,
generating the
autophagosome, a
distinctive double-membraned organelle. The
autophagosome then
joins the
lysosome to
create an autolysosome...
- "Ultrastructural
analysis of the
autophagic process in yeast:
detection of
autophagosomes and
their characterization".
Journal of Cell Biology. 124 (6): 903–913...
