-
Antifolates are a
class of
antimetabolite medications that
antagonise (that is, block) the
actions of
folic acid (vitamin B9).
Folic acid's
primary function...
- uses
active site
mutants in
BaDHFR to
guide lead
optimization for new
antifolate inhibitors. DHFR has been used as a tool to
detect protein–protein interactions...
- Kwon, Yun Kyung; Higgins,
Meytal B.; Rabinowitz,
Joshua D. (2010). "
Antifolate-Induced
Depletion of
Intracellular Glycine and
Purines Inhibits Thymineless...
- most
common cancer in children,
using aminopterin. This, and
another antifolate drug,
methotrexate used by Dr. Farber, were
discovered and
supplied by...
- and
antifolate pharmacology".
Seminars in Oncology. 24 (5
Suppl 18): S18-30-S18-39. PMID 9420019.
Gonen N, ****araf YG (August 2012). "
Antifolates in cancer...
- colestyramine, and dantrolene.
Methotrexate is an
antimetabolite of the
antifolate type. It is
thought to
affect cancer and
rheumatoid arthritis by two different...
-
along with a
delay in
mental and
physical development.
Valproate has
antifolate effects,
leading to
neural tube closure-related
defects such as spina...
- They are
treated after the
first trimester because pyrimethamine has an
antifolate effect, and lack of
folic acid can
interfere with
fetal brain formation...
-
appear to be
extremely rare.
Trachtman JN,
Pagano V (December 2015). "
Antifolates and MTHFR".
Therapeutic Drug Monitoring. 37 (6): 697–698. doi:10.1097/FTD...
- Immunoglobulin,
modulates the
immune system. IV N/A
Varies Methotrexate Antifolate;
inhibits dihydrofolate reductase. PO, IV, IM, SC, IT D (Au) Myeosuppression...
