Definition of Aminopterin. Meaning of Aminopterin. Synonyms of Aminopterin

- Aminopterin (or 4-aminopteroic acid), the 4–amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in...
- (hypoxanthine-aminopterin-thymidine medium) is a selection medium for mammalian cell culture, which relies on the combination of aminopterin, a drug that...
- Network. On 23 March, the New York State Food Laboratory reported that aminopterin was found in samples sent to them by Cornell. Michigan State University...
- therapeutic index of methotrexate was better than that of aminopterin, and clinical use of aminopterin was thus abandoned in favor of methotrexate.[citation...
- leukemias. Realizing this, he attempted to use a folate antagonist, aminopterin, to block the function of folic acid in patients with leukemia in hopes...
- is supplemented with hypoxanthine, aminopterin and thymidine, hence the name HAT medium. Antimetabolite aminopterin blocks the cellular biosynthesis of...
- are incubated in HAT medium (hypoxanthine-aminopterin-thymidine medium) for roughly 10 to 14 days. Aminopterin blocks the pathway that allows for nucleotide...
- Subbarow, known for the synthesis of the first ever chemotherapeutic drug aminopterin, and subsequently methotrexate. He is also known for the synthesis of...
- acute lymphocytic leukemia, the most common cancer in children, using aminopterin. This, and another antifolate drug, methotrexate used by Dr. Farber,...
- de novo purine synthesis pathway is also disrupted. Exposing cells to aminopterin (a folic acid analogue which inhibits dihydrofolate reductase) makes...