- amyloidosis, guillain-Barré syndrome.
Treatment Corticosteroids, low-dose
alkylators,
peripheral blood stem cell transplantation, high-dose chemotherapy. Medication...
- "DNA
damage responses triggered by a
highly cytotoxic monofunctional DNA
alkylator, hedamycin, a
pluramycin antitumor antibiotic".
Molecular Cancer Therapeutics...
- 3α,20β-Hydroxysteroid
Dehydrogenase with an Enzyme-Generated
Affinity Alkylator: Dual
Enzyme Activity at a
Single Active Site". Biochemistry. 19 (22):...
- HS (2000). "Can O6-alkylguanine-DNA
alkyltransferase depletion enhance alkylator activity in the clinic?" (PDF).
Clinical Cancer Research. 6 (8): 2967–8...
-
children 3
years of age and
older with
radiation therapy and high-dose
alkylator-based chemotherapy".
Journal of
Clinical Oncology. 23 (7): 1491–1499....
-
schematically below: Phosphorodiamidate-based, DNA-crosslinking, bis-
alkylator mustards have long been used
successfully in
cancer chemotherapy and include...
-
replication and
protein synthesis.
Since this drug is a
bifunctional alkylator, it can
react at two
different sites in the DNA,
forming intra- and interstrand...
- for the
effects of such
agents as
antitumor drugs, antibiotics, and DNA
alkylators.
Oxidation to a
reactive quinone methide is the
mechanistic basis of many...
-
antineoplastic agent that is
highly active toward AML,
unlike more
conventional alkylators like cyclophosphamide. The
FLAMSA protocol is most
often used as an induction...
- "First-in-human,
phase I/IIa
clinical study of the
peptidase potentiated alkylator melflufen administered every three w****s to
patients with
advanced solid...
