-
thioester with
coenzyme A (CoA): AcCH2C(O)−CoA + OH− → AcCH2CO−2 + H−CoA The
acetoacetyl-CoA
itself is
formed by
three routes: 3-hydroxy-3-methylglutaryl CoA...
-
Acetoacetyl CoA is the
precursor of HMG-CoA in the
mevalonate pathway,
which is
essential for
cholesterol biosynthesis. It also
takes a
similar role in...
-
acetyltransferases (ACAT), are
enzymes which convert two
units of acetyl-CoA to
acetoacetyl CoA in the
mevalonate pathway.
Thiolases are
ubiquitous enzymes that...
-
enzyme which catalyzes the
reaction in
which acetyl-CoA
condenses with
acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This
reaction comprises...
- Acetyl-CoA acetyltransferase, mitochondrial, also
known as
acetoacetyl-CoA thiolase, is an
enzyme that in
humans is
encoded by the ACAT1 (Acetyl-Coenzyme...
-
names 3-oxothiolase deficiency,
Mitochondrial acetoacetyl-coenzyme A
thiolase deficiency, Alpha-methyl-
acetoacetyl-CoA
thiolase deficiency Isoleucine...
-
occurs after acetoacetyl CoA formation. This
intermediate then
takes two
possible pathways:
acetoacetyl CoA →
acetoacetate →
acetone acetoacetyl CoA → butyryl...
- } 3-
acetoacetyl-CoA +
NADPH + H+ Thus, the two
substrates of this
enzyme are (S)-3-hydroxybutanoyl-CoA and NADP+; its 3
products are
acetoacetyl-CoA,...
-
mevalonate and
ketogenesis pathways. It is
formed from
acetyl CoA and
acetoacetyl CoA by HMG-CoA synthase. The
research of
Minor J. Coon and
Bimal Kumar...
- In enzymology, an
acetoacetyl-CoA
reductase (EC 1.1.1.36) is an
enzyme that
catalyzes the
chemical reaction (R)-3-hydroxyacyl-CoA + NADP+ ⇌ {\displaystyle...
