-
complex marks an
inhibitory chaperone called securin for
destruction by
ubiquitylating it.
Securin is a
protein which inhibits a
protease known as separase...
-
Although the
majority of
protein substrates are
ubiquitylated,
there are
examples of non-
ubiquitylated proteins targeted to the proteasome. The polyubiquitin...
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
Faustrup H,
Melander F,
Bartek J,
Lukas C, et al. (November 2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
- One
notable exception to this is p21 protein,
which appears to be
ubiquitylated using its N-terminal amine, thus
forming a
peptide bond with ubiquitin...
-
proteasome regulates protein expression and
function by
degradation of
ubiquitylated proteins, and also rids the cell of
abnormal or
misfolded proteins....
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
eukaryotic cells. It is best
known for its
intracellular role in
targeting ubiquitylated proteins for
degradation via the
ubiquitin proteasome system. Evidence...
- and
stability of Mdm2 are also
modulated by ubiquitylation. Mdm2 auto
ubiquitylates itself,
which allows for its
degradation by the proteasome. Mdm2 also...
-
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (November 2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
