- Subsequently,
proteins IKZF1, IKZF3, and CK1α are
recruited to the complex,
ubiquinated, and then
degraded by the proteasome. IKZF1 and IKZF3 are
essential transcription...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
-
irrelevant example: Dot1*‡ –
Methylates lysine 79 of
histone H3.) Bre1 –
Ubiquinates (adds
ubiquitin to)
lysine 123 of
histone H2B. ****ociated with pre-initiation...
-
serves as a
signaling molecule to the proteasomes,
which then bind to the
ubiquinated proteins and
degrades them. This ubiquitin-proteasome
system acts as...
-
certain apoptotic pathways, and if absent,
leads to the
formation of
ubiquinated inclusions.
Experiments in mice with
neuronally confined macroautophagy-gene...
- ubiquitin-proteasome
system (UPS). This
consists of an E1-E2-E3
pathway that
ubiquinates proteins to mark them for degradation. In eukaryotes, the
proteins get...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
-
Degradation of LDL
Receptor Protein (IDOL) is a
ubiquitin ligase that
ubiquinates LDL
receptors in
endosomes and
directs the
receptors to the lysosomal...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
- mono-ubiquitinated isoform. In normal, non-mutant cells, FANCD2 is mono-
ubiquinated in
response to DNA damage.
FANCE together with
FANCC acts as the substrate...
