- Subsequently,
proteins IKZF1, IKZF3, and CK1α are
recruited to the complex,
ubiquinated, and then
degraded by the proteasome. IKZF1 and IKZF3 are
essential transcription...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
- (FBXO4) via an
intermolecular beta
sheet interaction. TRF1
cannot be
ubiquinated while telomere bound,
likely because the same TRF1
domain that binds...
- mono-ubiquitinated isoform. In normal, non-mutant cells, FANCD2 is mono-
ubiquinated in
response to DNA damage.
FANCE together with
FANCC acts as the substrate...
-
reductase has not been demonstrated).
Lysine residues 89 and 248 can
become ubiquinated by ER-resident E3 ligases. The
identity of the
multiple E3
ligases involved...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
-
certain apoptotic pathways, and if absent,
leads to the
formation of
ubiquinated inclusions.
Experiments in mice with
neuronally confined macroautophagy-gene...
-
components and
organelles are
rapidly degraded.
Mitochondria are
rapidly ubiquinated and destro****.
Oxidative stress theory is a
hypothesis that it is evolutionarily...
- The E3
ubiquitin ligase is able to
recognize misfolded proteins and
ubiquinate them. HDAC6 can then bind to the
ubiquitin and the
motor protein dynein...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
