-
Sheddases are membrane-bound
enzymes that
cleave extracellular portions of
transmembrane proteins,
releasing the
soluble ectodomains from the cell surface...
- of body
parts Desquamation,
pathologic or non-pathologic skin
shedding Sheddase and
Ectodomain shedding Shedding game, a
family of card
games where the...
-
examples of
enzymes that can
induce shedding of the
glycocalyx and
these sheddases can
therefor contribute to
degradation of the
glycocalyx layer in several...
- interactions.
Those ADAMs which are
active proteases are
classified as
sheddases because they cut off or shed
extracellular portions of
transmembrane proteins...
-
unique structure,
possessing both
potential adhesion and
protease domains.
Sheddase, a
generic name for the ADAM metallopeptidase,
functions primarily to cleave...
- loss of
glycocalyx and is
therefore considered as a
potential endogenous sheddase. However,
plasma hyaluronidase activity is
decreased in
experimental as...
-
transmembrane domain by
another enzyme known as ADAM17 a
member of the
sheddase enzyme family,
during the
protective phase of RAAS, the Renin–Angiotensin–Aldosterone...
-
approximately 60
amino acids. Its main
binding partner is the ADAM10 protein, a
sheddase that
interacts with a
variety of
adhesion molecules that are
found on the...
- pro-TNF-α), and is of
known physiological importance. ADAM17 was the
first '
sheddase' to be identified, and is also
understood to play a role in the release...
-
Aderbasib (codenamed INCB7839) is a
sheddase inhibitor that may
suppress tumor cell proliferation.
Acting on
multiple receptor classes and subclasses,...
