- ADAM10, have been
identified as
possessing alpha-
secretase activity. Upon
cleavage by
alpha secretases, APP
releases its
extracellular domain - a fragment...
-
Secretases are
enzymes that "snip"
pieces off a
longer protein that is
embedded in the cell membrane.
Among other roles in the cell,
secretases act on...
-
Gamma secretase is a multi-subunit
protease complex, an
integral membrane protein, that
cleaves single-p****
transmembrane proteins at
residues within...
- Beta-
secretase 1, also
known as beta-site
amyloid precursor protein cleaving enzyme 1, beta-site APP
cleaving enzyme 1 (BACE1), membrane-****ociated aspartic...
-
proteolytic enzymes α-, β- and γ-
secretase; Aβ
protein is
generated by
successive action of the β and γ
secretases. The γ
secretase,
which produces the C-terminal...
- Beta-
secretase is a
protein family that
includes in
humans Beta-
secretase 1 and Beta-
secretase 2.
Tallon C,
Farah MH (October 2017). "Beta
secretase activity...
- Beta-
secretase 2 (EC 3.4.23.45, also
known as Memapsin-1) is an
enzyme that
cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the
Swedish variant of Alzheimer's...
- survival, and post-injury repair. In Alzheimer's disease,
gamma secretase and beta
secretase act
together in a
proteolytic process which causes APP to be...
- hephaestin). The amyloid-β
precursor protein (AβPP), and all ****ociated
secretases, are
expressed early in
development and play a key role in the endocrinology...
- therapy.
Other methods being studied include the use of antioxidants,
gamma secretase inhibition,
adrenergic agonists, and memantine.
Research is
often carried...
