- Bodroux-Chichibabin
aldehyde synthesis, for example:
RMgBr + HC(OC2H5)3 → RC(H)(OC2H5)2 + Mg
Br(OC2H5) RC(H)(OC2H5)2 + H2O → RCHO + 2 C2H5OH In coordination...
- 4 RLi → R4Pb + 4 LiCl + Pb 2 PbCl2 + 4
RMgBr → R4Pb + Pb + 4 Mg
BrCl 3 PbCl2 + 6
RMgBr → R3Pb-PbR3 + Pb + 6 Mg
BrCl
These reactions produce derivatives that...
- CH 2 ) O +
RMgBr ⟶ R − CH 2 CH 2 − OMg
Br → H 2 O R − CH 2 CH 2 − OH
primary alcohol {\displaystyle {\ce {(CH2CH2)O{}+
RMgBr->R-CH2CH2-OMg
Br->[{\ce {H2O}}]{\overset...
- (sometimes
called phosphanes) such as triphenylphosphine, Ph3P. 3
RMgBr + PCl3 → R3P + 3 Mg
BrCl
Triphenylphosphine is
produced industrially by the reaction...
- Corey–House
synthesis 1967 R2CuLi or
RMgX sp3 R-X sp2, sp3 Cu Cu-catalyzed
version by Kochi, 1971
Kumada coupling 1972
RMgBr sp2, sp3 R-X sp2 Pd or Ni or Fe...
-
tetraaryltin compounds can be
prepared using Grignard reagents: SnCl 4 + 4
RMgBr → R 4Sn + 4 Mg
BrCl The
mixed halide-alkyls,
which are more
common and more important...
- to
enones with organocuprates. Note that if a
Grignard reagent (such as
RMgBr) is used, the
reaction with an
enone would instead proceed through a 1,2-addition...
- diphenyl****nic compounds, e.g. by
reactions with
Grignard reagents:
RMgBr + (C6H5)2AsCl → (C6H5)2AsR + Mg
BrCl (R = alkyl, aryl)
Diphenylchlorarsine was used as a chemical...
- acid (tolerating
higher operating temperature than
corresponding RLi or
RMgBr counterparts),
sulfur dioxide and
isocyanates behaving like soft Grignard...
-
deprotonated 1,3-****tones and
related acidic substrates, the
Grignard reagent RMgX
functions merely as a base,
giving the
enolate anion and
liberating the...
