- DNA-PKcs, is an
enzyme that in
humans is
encoded by the gene
designated as
PRKDC or XRCC7. DNA-PKcs
belongs to the
phosphatidylinositol 3-kinase-related...
-
laboratory rat
models were
created in 2022, one
having Prkdc knocked out, the
other having both
Prkdc and Rag2
knocked out.
Severe combined immunodeficiency...
- C57BL/Ka and BALB/c mice,
featuring a loss of
function mutation in the
PRKDC gene. The
PRKDC gene
product is
necessary for
resolving breaks in DNA
strands during...
-
Navajo and
Apache po****tion
causes SCID and
radiation intolerance.
PRKDC PRKDC or DNA-PKcs is a gene
required for DNA
repair and V(D)J recombination...
-
Fabien N, Ménétrier-Caux C, De
Villartay JP,
Walzer T,
Belot A (2015)
PRKDC mutations ****ociated with immunodeficiency, granuloma, and
autoimmune regulator-dependent...
- and many
other phenomena. In 2019
researchers published a
crossing of a
prkdc-/- and a IL2rga-/-
strain that
produced transparent,
immunodeficient offspring...
- Q15139 12831 PRKD2 HGNC:17293 Q9BZL6 12832 PRKD3 HGNC:9408 O94806 12833
PRKDC HGNC:9413 P78527 12834 PRKG1 HGNC:9414 Q13976 12835 PRKG2 HGNC:9416 Q13237...
-
Prkdcscid is a loss-of-function
mutation in the
mouse homologue of the
human PRKDC gene,
which encodes a
protein that
resolves DNA
strand breaks that occur...
-
endonuclease activity on 5' and 3'
overhangs and
hairpins when
complexed with
PRKDC.
Artemis plays an
essential role in V(D)J recombination, the
process by...
-
mutation in the gene for
protein kinase, DNA activated,
catalytic polypeptide (
PRKDC),
which plays a role in
repairing double-stranded DNA breaks. This has implications...
