-
Polyglutamylation is a form of
reversible posttranslational modification of
glutamate residues seen for
example in
alpha and beta tubulins, nucleosome...
-
methotrexate exists.
Although the
mechanism is not very clear, the
polyglutamylation of
methotrexate and
dihydrofolate in
malignant cells is considered...
-
acetylation in the
structure and
function of
microtubules remains elusive.
Polyglutamylation: the
addition of a
glutamate polymer (typically 4-6
residues long)...
- ADP-ribosylation
Glutamate Carboxylation ADP-ribosylation
Methylation Polyglutamylation Polyglycylation Asparagine Deamidation Glycosylation Glutamine Transglutamination...
-
formation amino acid
addition arginylation, a tRNA-mediation
addition polyglutamylation,
covalent linkage of
glutamic acid
residues to the N-terminus of tubulin...
- proteins.
These modifications include detyrosination, acetylation,
polyglutamylation, polyglycylation, phosphorylation, ubiquitination, sumoylation, and...
-
translational modifications;
however the two of most
regarded interest are
polyglutamylation and polyglycylation. Both
modifications are
similar in the
sense they...
- PMC 65034. PMID 11752472.
Cherest H,
Thomas D, Surdin-Kerjan Y (2000). "
Polyglutamylation of
folate coenzymes is
necessary for
methionine biosynthesis and maintenance...
-
GARFT and
thymidylate synthase.
Raltitrexed is
fully active after polyglutamylation,
which allows cellular retention of the drug. By
inhibiting Thymidylate...
-
discovered in Paramecium, and
later shown in
mammalian neurons as well.
Polyglutamylation Redeker V,
Levilliers N,
Schmitter JM, Le Caer JP,
Rossier J, Adoutte...
