- An
oxysterol is a
derivative of
cholesterol obtained by
oxidation involving enzymes and / or pro-oxidants. Such
compounds play
important roles in various...
-
Oxysterol-binding protein-related
protein 2 is a
protein that in
humans is
encoded by the OSBPL2 gene. This gene
encodes a
member of the
oxysterol-binding...
-
Oxysterol-binding protein-related
protein 1 is a
protein that in
humans is
encoded by the OSBPL1A gene. This gene
encodes a
member of the
oxysterol-binding...
- The
oxysterol-binding
protein (OSBP)-related
proteins (ORPs) are a
family of
lipid transfer proteins (LTPs). Concretely, they
constitute a
family of sterol...
- EBI2 is a
receptor for
oxysterols. The most
potent activator is 7α,25-dihydroxycholesterol (7α,25-OHC), with
other oxysterols exhibiting varying affinities...
-
interest in
oxysterols arose when they were
shown to
exert inhibitory actions on
cholesterol biosynthesis. This
finding became known as the "
oxysterol hypothesis"...
- 14.13.100, 25-hydroxycholesterol 7alpha-monooxygenase, CYP7B1, CYP7B1
oxysterol 7alpha-hydroxylase) is an
enzyme with
systematic name cholest-5-ene-3beta...
-
classified as
orphan nuclear receptors, however, upon
discovery of
endogenous oxysterols as
ligands they were
subsequently deorphanized. Two
isoforms of LXR have...
- is
absorbed into the
mouse bloodstream. It
increases the
production of
oxysterols in
macrophages and plaques,
which causes the
activation of LXR in macrophages...
- (STARD1) MLN64 (STARD3)
These proteins are
involved in
cholesterol and
oxysterol transport STARD4 STARD5 STARD6
Phosphatidylcholine transfer protein (PCTP/STARD2)...
