- via
mitochondrial metabolism.
Oncometabolite production is
another example of
metabolic deregulation.
Oncometabolites are
metabolites whose abundance...
- alpha-ketoglutarate or the GABA shunt.[citation needed]
Succinate is one of
three oncometabolites,
metabolic intermediates whose ac****ulation
causes metabolic and non-metabolic...
-
which serve to
facilitate tumorigenesis,
dubbed oncometabolites.
Among the best
characterized oncometabolites is 2-hydroxyglutarate
which is
produced through...
- (2018-01-17). "Metabolic
Alterations in
Cancer Cells and the
Emerging Role of
Oncometabolites as
Drivers of
Neoplastic Change". Antioxidants. 7 (1): 16. doi:10.3390/antiox7010016...
- dehydrogenase-1
inhibitor that
works by
decreasing abnormal production of the
oncometabolite 2-hydroxyglutarate (2-HG),
leading to
differentiation of
malignant cells...
- Tian YM,
Hillringhaus L, Bagg EA, Rose NR, et al. (May 2011). "The
oncometabolite 2-hydroxyglutarate
inhibits histone lysine demethylases". EMBO Reports...
-
metabolic enzymes IDH1 and IDH2,
which lead to the
generation of a
novel oncometabolite, D-2-hydroxyglutarate,
which inhibits the
activity of
epigenetic enzymes...
-
involvement of
particular enzymes such as PKM2,
mutated IDH as well as
novel oncometabolites such as 2-hydroxyglutarate in
cancer development have once
again brought...
- Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu Lx (2011-01-18). "
Oncometabolite 2-Hydroxyglutarate Is a
Competitive Inhibitor of α-Ketoglutarate-Dependent...
-
seizures in
childhood epilepsy 2-Hydroxyglutarate (2HG): 71–72 1.90
Oncometabolite (cancer-causing) Part of
butanoate metabolic pathway None
Elevated levels...
